Detailed view for TcCLB.509695.90

Basic information

TDR Targets ID: 53366
Trypanosoma cruzi, intraflagellar transport protein 172, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.0963 | Length (AA): 1747 | MW (Da): 197115 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 317 1got (B) 43 340 14.00 0 1 0.1 -0.37
13 557 1nr0 (A) 56 610 14.00 0 1 0.35 0.38
1502 1606 1elr (A) 223 327 12.00 0.00000068 0.01 0.3 -1.36
10 262 2ghs (A) 30 278 10.00 0 1 0.21442 0.11
16 272 1q7f (A) 780 1030 12.00 0 0.91 0.313709 -0.16
19 94 3ow8 (A) 151 219 32.00 0.5 0.63 0.329403 -0.1
19 340 2ymu (A) 19 306 26.00 0.00000082 1 0.398216 -0.01
1104 1402 5cqr (A) 867 1115 27.00 0.11 0.96 0.175051 0.85
1164 1463 1b89 (A) 1191 1516 18.00 0 1 0.195323 0.6
1388 1501 5hrz (A) 13 122 8.00 0.0025 0.1 0.125355 -0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130417)

Species Accession Gene Product
Caenorhabditis elegans CELE_T27B1.1   Protein OSM-1
Drosophila melanogaster Dmel_CG13809   Outer segment 2
Echinococcus granulosus EgrG_000617200   intraflagellar transport protein 172
Echinococcus multilocularis EmuJ_000617200   intraflagellar transport protein 172
Giardia lamblia GL50803_17105   IFT complex B
Homo sapiens ENSG00000138002   intraflagellar transport 172
Leishmania braziliensis LbrM.21.1210   hypothetical protein, conserved
Leishmania donovani LdBPK_211220.1   intraflagellar transport protein 172, putative
Leishmania infantum LinJ.21.1220   hypothetical protein, conserved
Leishmania major LmjF.21.0980   hypothetical protein, conserved
Leishmania mexicana LmxM.21.0980   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04604   hypothetical protein
Loa Loa (eye worm) LOAG_14257   hypothetical protein
Loa Loa (eye worm) LOAG_13357   hypothetical protein
Mus musculus ENSMUSG00000038564   intraflagellar transport 172
Neospora caninum NCLIV_040690   selective LIM-binding factor, putative
Schistosoma japonicum Sjp_0034460   Intraflagellar transport protein 172 homolog, putative
Schistosoma mansoni Smp_130830   wimple/ift172
Schmidtea mediterranea mk4.000070.26   IFT172-like protein
Trypanosoma brucei gambiense Tbg972.10.1210   hypothetical protein, conserved
Trypanosoma brucei Tb11.0560   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.1170   intraflagellar transport protein 172
Trypanosoma brucei Tb11.v5.0858   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_10_970   intraflagellar transport protein 172, putative
Trypanosoma cruzi TcCLB.509695.90   intraflagellar transport protein 172, putative
Toxoplasma gondii TGME49_288050   intraflagellar transport protein 172, putative
Trichomonas vaginalis TVAG_327960   wimple/ift172, putative
Trichomonas vaginalis TVAG_061760   osm-1, putative

Essentiality

TcCLB.509695.90 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.1170 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.1170 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.1170 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.1170 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.509695.90 (Trypanosoma cruzi), intraflagellar transport protein 172, putative
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